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APC-Labeled Human Mucin-1 / MUC-1 Protein, His Tag (Site-specific conjugation)

Product Number/Spec
Price
Menge
MU1-HA2H8-25tests
$360.00
MU1-HA2H8-200tests
$2245.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1, SEC, MUC-1, X, MUC1, ZD, PEM, PEMT, PUM, CA15-3, Episialin

  • Source

    APC-Labeled Human Mucin-1 Protein, His Tag (MU1-HA2H8) is produced via conjugation of APC to Human Mucin-1 Protein, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human Mucin-1 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 890 - Gly 1158 (Accession # P15941-1).

    Predicted N-terminus: Ser 890 & Ser 1098

    Request for sequence

  • Molecular Characterization

    Mucin-1 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 21.3 kDa & 10.2 kDa.

  • Conjugate

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • Application

    Please note that this product is NOT compatible to streptavidin detection system.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • Bioactivity-FACS

     Mucin-1 FACS

    5e5 of anti-Mucin-1 (F1C) CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Mucin-1 Protein, His Tag (Cat. No. MU1-HA2H8) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

    Protocol

User Reviews
Publish Comment

Background Introduction

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants

Frontier Progress

 
Drug Development Progress
  • English Name:

    Mucin-1

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    28 Details

  • Highest R&D Stage:

    Phase 2 Clinical

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