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APC-Labeled Human HLA-A*02:01&B2M&MAGE-A2 (KMVELVHFL) Tetramer Protein

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HLM-HA2H3-25ug
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HLM-HA2H3-200ug (100ug X 2)
$2,350.00
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HLM-HA2H3
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Synonyms

HLA-A*0201 & B2M & MAGE-A2 (KMVELVHFL)

Source

APC-Labeled Human HLA-A*02:01&B2M&MAGE-A2 (KMVELVHFL) Tetramer Protein (HLM-HA2H3) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & KMVELVHFL peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & KMVELVHFL).

Predicted N-terminus: Gly 25 & Ile 21

Molecular Characterization

APC-Labeled Human HLA-A*02:01&B2M&MAGE-A2 (KMVELVHFL) Tetramer Protein is assembled by biotinylated monomer and APC-labeled streptavidin.

Biotinylated Human HLA-A*02:01&B2M&MAGE-A2 (KMVELVHFL) Complex Protein is produced by co-expression of HLA and B2M loaded with MAGE-A2 peptide. Biotinylated Human HLA-A*02:01&B2M&MAGE-A2 (KMVELVHFL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

Conjugate

APC

Excitation Wavelength: 640 nm

Emission Wavelength: 661 nm

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, 1% BSA, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background Introduction

HLA-A*0201, a prevalent human MHC class I allele, assembles with β2-microglobulin (B2M) and the MAGE-A2-derived peptide KMVELVHFL to form a peptide-MHC complex. MAGE-A2 belongs to cancer-testis antigen family, which is largely silenced in normal somatic tissues but reactivated in multiple malignant tumors. It promotes tumor progression and immune escape, representing a promising target for tumor immunotherapy. This cell-surface complex can be specifically recognized by CD8⁺ cytotoxic T lymphocytes, supporting the development of antigen-specific T cell research and cancer vaccine design.