Mein Warenkorb

APC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag (Site-specific conjugation)

User Reviews
Product Number/Spec
Price
Menge
GUC-HA2H4-25tests
$360.00
GUC-HA2H4-200tests
$2245.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    GUCY2C, GUC2C, STAR, STA receptor, hSTAR, GC-C

  • Source

    APC-Labeled Human GUCY2C Protein, His Tag (GUC-HA2H4) is produced via conjugation of APC to Human GUCY2C Protein, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human GUCY2C Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1).

    Predicted N-terminus: Ser 24

    Request for sequence

  • Molecular Characterization

    GUCY2C Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 49.6 kDa.

  • Conjugate

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • Application

    Please note that this product is NOT compatible to streptavidin detection system.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

Kunden haben auch angesehen

Data Display

  • Bioactivity-FACS

     GUCY2C FACS

    5e5 of anti-GUCY2C CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human GUCY2C Protein, His Tag (Cat. No. GUC-HA2H4) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

    Protocol

User Reviews
Publish Comment

Background Introduction

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Heat-stable enterotoxin receptor

  • Category:

  • Listed Drugs Count:

    1 Details

  • Clinical Drugs Count:

    10 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
More
  • Basic Product Information
  • Product Details
  • Kunden haben auch angesehen
  • Data Display
  • User Reviews
  • Hintergrund
Kontaktieren Sie uns