Human CXCR2 Full Length Protein (VLP)

AIDD‑Ready
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CX2-H52P4-20ug
$620.00
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CX2-H52P4-100ug
$1,235.00
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CX2-H52P4-500ug (250ug X 2)
$4,305.00
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CX2-H52P4
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  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
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Application
  • Immunization
  • Cell based assay (FACS or functional assay)
  • Screening (ELISA)
Synonyms

CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, CXCR2, CXC-R2, CXCR-2, GRO, MGSA receptor, IL-8R B

Source

Human CXCR2 Full Length Protein (VLP) (CX2-H52P4) is expressed from human 293 cells (HEK293). It contains AA Glu 2 - Leu 360 (Accession # NP_001548.1).

Predicted N-terminus: Asp

Molecular Characterization

*The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow the link for product information.

Structure

Virus-like particles (VLPs) are protein particles that mimic the shape of viruses but lack a viral genome, and incorporating transmembrane proteins on the external surface.

Synthesis Process

Envelope virus-like particles (eVLPs) are produced by co-expressing target membrane proteins with viral structural proteins in mammalian cells, enabling native embedding of membrane proteins into the lipid bilayer during VLP budding. This approach preserves authentic conformation, post-translational modifications, and orientation, while creating a completely detergent-free environment with repetitive multivalent display and strong immunogenicity making them ideal for immunization, binding assays in antibody discovery and screening (ELISA), and cell-based assays such as FACS, etc.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Formulation

The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 12 months under sterile conditions.

Background

CXCR2 is a chemokine receptor mediating neutrophil recruitment and angiogenesis via ELR+ CXC chemokines (IL-8). It is a central driver of tumor-promoting inflammation and myeloid-derived suppressor cell (MDSC) accumulation. CXCR2 antagonists aim to remodel the tumor immune microenvironment and enhance checkpoint inhibitor efficacy.