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Product Details
Synonyms
CEACAM6, CD66c, CEAL, NCA
Source
Rhesus macaque CEACAM-6, His Tag (CE6-R52H6) is expressed from human 293 cells (HEK293). It contains AA Gln 35 - Gly 320 (Accession # XP_014979566.2).
Predicted N-terminus: Gln 35
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 33.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Rhesus macaque CEACAM-6, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.
Bioactivity-ELISA
Immobilized Rhesus macaque CEACAM-6, His Tag (Cat. No. CE6-R52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CEACAM-8, His,Avitag (Cat. No. CE8-H82E9) with a linear range of 0.039-2.5 μg/mL (QC tested).
Protocol
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FAQ
- Product
Are there any studies showing that CEACAM6 and CEACAM8 can interact?
Yes. According to the reference “Diverse oligomeric states of CEACAM IgV domains” (PNAS), CEACAMs can form homophilic and/or heterophilic interactions (e.g., CEACAM6–CEACAM8, CEACAM5–CEACAM6). Structural studies of the CEACAM6–CEACAM8 heterodimer showed that the addition of CEACAM8 to CEACAM6 led to heterodimer formation, confirming their ability to bind each other.
Background
Recent Advances
Drug Development Progress- English Name：
Carcinoembryonic antigen related cell adhesion molecule 6
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
3 Details
- Highest Development Stage：
Phase 2 Clinical
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