Monoclonal Anti-PD-L1 Antibody, Mouse IgG1 (1G1)

描述/背景（Background）

Programmed death ligand 1 (PD-L1) is the principal ligand of programmed death 1 (PD-1), a coinhibitory receptor that can be constitutively expressed or induced in myeloid, lymphoid, normal epithelial cells and in cancer. A key immune checkpoint is triggered when PD-1 (programmed cell death protein 1) engages its ligand PD-L1. As a result of this interaction, T cell activation is attenuated and an active immune response is prevented.
This mechanism is often co-opted by tumors. PD-L1 is upregulated in several tumor types and contributes to the malignancy of these cancers by interacting with PD-1 and inhibiting T cell activation. In this way, the tumors avoid detection and destruction by the immune system. Accordingly, PD-1 and PD-L1 have garnered much attention for their roles in tumor immunology and as immune-based therapeutic targets.

种属（Host Species）

Mouse

克隆号（Clone）

1G1

适用方法（Application）

IHC

效价（Property）

1：500

状态（State）

Liquid

阳性对照（Positive Control）

Human Tonsil Tissues

克隆类型（Clonality）

Monoclonal

分子别名（Synonym）

PDL1, PD-L1, CD274, B7-H1, B7H1

研究领域（Research Field）

Cancer Drug Targets

抗体来源（Source）

Mouse

同种型（Isotype）

IgG

储存（Storage）

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.