ADC Isotype Control Mouse IgG2a (Exatecan)

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DNP-DM487-100ug
$195.00
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DNP-DM487-1mg
$790.00
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Source

Chimeric ADC Isotype Control Mouse IgG2a (Exatecan) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to mouse IgG2a constant domains.

Antibody Type

Recombinant Monoclonal

Clone

AM487

Isotype

Mouse IgG2a, Kappa

Host Species

Mouse

Purification

Protein A purified.

Aggregation

Less than 10%, as determined by SEC-MALS.

Concentration

Please refer to the Certificate of Analysis (CoA).

Form

Lyophilized

Formulation

Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

Please contact us for customized product forms or formulations.

Reconstitution

Please refer to the Certificate of Analysis (CoA) for specific instructions.

Shipping

Lyophilized product is shipped at ambient temperature.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
Notices

Product Specific Notices: For research use only.

Background

Exatecan is a semi-synthetic camptothecin-derived topoisomerase I inhibitor. It specifically binds to and inhibits topoisomerase I, blocking DNA replication and transcription processes to potently suppress tumor cell proliferation. As a highly active cytotoxic payload, it serves as a core component of multiple antibody-drug conjugates (ADCs) and is widely used in the research, development and clinical translation of targeted anti-tumor ADC drugs.