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Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (3G1)

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Product Number/Spec
Price
Availability
Menge
GLO-MY2286-100ug
$360.00
In Stock - Delivery in 2-3 business days
GLO-MY2286-1mg (500ug X 2)
$2380.00
In Stock - Delivery in 2 weeks
Gesamtanzahl Product Amount$ 0

Product Details

  • Source

    Chimeric Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (3G1) is recombinantly expressed in HEK293. It consists of mouse variable regions genetically fused to human IgG1 constant domains.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    3G1

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant Human cytomegalovirus (strain AD169) (HHV-5) Glycoprotein H&L&O is expressed from human 293 cells

  • Specificity

    Specifically recognizes Human cytomegalovirus (strain AD169) (HHV-5) Glycoprotein H&L&O.

  • Application

    Application
    Recommended Use / Performance
    ELISA
    0.2-2 μg/mL
  • Purification

    Protein A purified.

  • Aggregation

    Less than 10%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • Bioactivity-ELISA

     Glycoprotein H & Glycoprotein L & Glycoprotein O/gH & gL & gO (HCMV) ELISA

    Immobilized Human cytomegalovirus (strain AD169) (HHV-5) Glycoprotein H&L&O, His Tag (Cat. No. GLO-V5243) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (3G1) (Cat. No. GLO-MY2286) with a linear range of 0.06-2 ng/mL (QC tested).

    Protocol
  •  Glycoprotein H & Glycoprotein L & Glycoprotein O/gH & gL & gO (HCMV) ELISA

    Immobilized HHV-5 (strain AD169) Glycoprotein H&L, His Tag (Cat. No. GHL-H5243) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human Cytomegalovirus (strain AD169) Glycoprotein H&L&O Antibody, Human IgG1 (3G1) (Cat. No. GLO-MY2286) with a linear range of 0.06-2 ng/mL (Routinely tested).

    Protocol

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Publish Comment

FAQ

  • product

    Can lyophilized proteins remain stable during room-temperature shipping or temporary room-temperature exposure?

    In general, lyophilized proteins remain stable during room-temperature shipping or temporary exposure to room-temperature conditions.


    Many ACROBiosystems recombinant proteins are supplied in lyophilized (freeze-dried) form. The lyophilization process effectively removes moisture from the product, helping reduce degradation-related reactions and improve protein stability during transportation and storage.


    To evaluate the stability of lyophilized proteins under normal temperature conditions, ACROBiosystems conducted a stability study on 11 representative lyophilized protein products at 37°C. The study demonstrated that these proteins maintained good quality stability after storage at 37°C for approximately 20 days. Based on these validation results, temporary room-temperature exposure during shipping or handling is generally not expected to have a significant impact on product quality or downstream application performance.


    To ensure optimal long-term stability, products should be stored according to the storage conditions specified in the product Certificate of Analysis (COA) upon receipt.


    Supporting Document


Background Introduction

Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.

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