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PE-Labeled Monoclonal Anti-Human CD279 (PD-1) Antibody, Mouse IgG2b (AS630) (0.03% Proclin)

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FABm044-01-200tests (50tests X 4)
$550.00
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AS630

Isotype

Mouse IgG2b, Kappa

Host Species

Mouse

Reactivity

Human

Immunogen

Purified Human CD279 Protein

Conjugate

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

Specificity

This product is a specific antibody specifically reacts with CD279 protein.

Application

Flow Cytometry (Detection the expression of CD279 on Human cells).

Recommended Dilution

1:20

Isotype Control

The isotype control is sold separately; please refer to Cat. No. DNP-PM486 for product information.

Form

Liquid

Formulation

Supplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.

Please contact us for customized product forms or formulations.

Shipping

Liquid product is shipped at blue ice.

Storage

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • Store at 2-8 °C for 12 months.
Notices

Product Specific Notices: For research use only.

ACRO Quality Management System

Background Introduction

CD279, or programmed cell death protein 1 (PD-1), is a 55 kD member of the immunoglobulin superfamily with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic region. It is mainly expressed on activated T cells, B cells and myeloid cells, and negatively regulates immune responses by binding to its ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), thereby inhibiting T cell proliferation and cytokine secretion. Dysregulatio of the PD-1 pathway is linked to autoimmune diseases (e.g, rheumatoid arthritis, systemic lupus erythematosus) and tumor immune escape, makin it a key target for cancer immunotherapy. The antibody PE, anti-Human CD279 (PD-1)-AS630 binds specifically to CD279, facilitating relevant research.