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Laminin 521 E8

Produktanfrage

Laminin 521 E8 Molekülhintergrund

Laminin 521 were expressed in Descemet's membrane and corneal endothelium. This laminin isoform significantly enhanced the in vitro adhesion and proliferation, and differentiation of HCECs. Laminin 511-E8 consists of the C-terminal end of the alpha 5, beta 2, and gamma 1 chains.

Klinische Arzneimittelinformation

Englischer NameForschungscodeForschungsphaseFirmaIndikationenKlinische Studie
Ifinatamab deruxtecanMK-2400; DS-7300a; DS-7300; MABX-9001a; I-DXdPhase 3 ClinicalDaiichi Sankyo Co LtdSolid tumours; Small Cell Lung Carcinoma; Esophageal Squamous Cell Carcinoma
Details
YL-201YL-201; YL201Phase 3 ClinicalMediLink Therapeutics Co LtdSolid tumours; Small Cell Lung Carcinoma; Prostatic Neoplasms, Castration-Resistant; Nasopharyngeal Carcinoma
Details
HS-20093HS-20093; HS20093; GSK5764227; GSK-5764227Phase 3 ClinicalShanghai Hansoh Biomedical Co LtdSolid tumours; Esophageal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Neoplasms; Soft Tissue Neoplasms; Prostatic Neoplasms, Castration-Resistant; Osteosarcoma; Sarcoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung
Details
B7-H3 CAR-T cell therapy (Boyuan Runsheng Pharma)Phase 2 ClinicalBoyuan Runsheng Pharma (Hangzhou) Co LtdSolid tumours; Glioblastoma
Details
ObrindatamabMGD-009; B7-H3 x CD3Phase 2 ClinicalMacrogenics IncMesothelioma; Carcinoma, Non-Small-Cell Lung; Melanoma; Thyroid Neoplasms; Sarcoma; Neuroblastoma; Neurofibrosarcoma; Prostatic Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Sarcoma, Synovial; Urinary Bladder Neoplasms; Wilms Tumor; Pancreatic Neoplasms; Colonic Neoplasms; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Rhabdomyosarcoma
Details
Vobramitamab duocarmazineMGC-018Phase 2 ClinicalMacrogenics IncLiver Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Anus Neoplasms; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Carcinoma, Ovarian Epithelial; Prostatic Neoplasms, Castration-Resistant; Prostatic Neoplasms; Laryngeal Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Small Cell; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Melanoma
Details
TAK-280MVC-280; TAK-280Phase 2 ClinicalMaverick Therapeutics IncSolid tumours; Neoplasms; Neoplasm Metastasis
Details
4SCAR-2764SCAR-276Phase 2 ClinicalShenzhen Geno-Immune Medical InstituteSolid tumours
Details
IBI129IBI-129; IBI129Phase 2 ClinicalInnovent Biologics(Suzhou) Co LtdSolid tumours
Details
7MW37117-MW-3711; 7MW3711Phase 2 ClinicalMabwell (Shanghai) Bioscience Co LtdSolid tumours; Neoplasms
Details
IBI334IBI334; IBI-334Phase 2 ClinicalInnovent Biologics(Suzhou) Co LtdSolid tumours; Neoplasms
Details
MHB088CMHB-088CPhase 2 ClinicalMinghui Pharmaceutical Pty LtdSolid tumours
Details
DB-1311DB-1311; BNT-324Phase 2 ClinicalSolid tumours; Neoplasm Metastasis
Details
IBB-0979IBB0979; IBB-0979Phase 2 ClinicalSunHo (China) BioPharmaceutical Co LtdSolid tumours; Neoplasms
Details
ILB-3101ILB-3101Phase 2 ClinicalInnolake Biopharm (Hangzhou) Co LtdSolid tumours; Neoplasms
Details
Fully Human B7H3 CAR-T Cells TherapyfhB7H3.CAR-TsPhase 2 ClinicalThe Affiliated Hospital Of Xuzhou Medical UniversityOvarian Neoplasms; Carcinoma, Hepatocellular
Details
CD-276-targeted Chimeric Antigen Receptor T Cell TherapyCD276 CAR-TPhase 2 ClinicalShenzhen University General HospitalPancreatic Neoplasms
Details
EnoblituzumabMGA-271; TJ271Phase 2 ClinicalMacrogenics IncCarcinoma, Transitional Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Osteosarcoma; Neuroblastoma; Sarcoma, Ewing; Prostatic Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Ovarian Neoplasms; Neoplasms; Triple Negative Breast Neoplasms; Wilms Tumor; Carcinoma, Renal Cell; Desmoplastic Small Round Cell Tumor; Abdominal Neoplasms; Squamous Cell Carcinoma of Head and Neck; Solid tumours; Rhabdomyosarcoma; Head and Neck Neoplasms
Details
124I-omburtamab124I-8H9; 124I-8H9-(B7-H3)Phase 1 ClinicalMemorial Sloan Kettering Cancer Center, Y-Mabs Therapeutics IncBrain Neoplasms; Glioma
Details
Mirzotamab clezutoclaxABBV-155Phase 1 ClinicalAbbvie IncSolid tumours
Details
SCRI-CARB7H3SCRI-CARB7H3Phase 1 ClinicalSeattle Children'S HospitalNeuroblastoma; Choroid Plexus Neoplasms; Neoplasms, Germ Cell and Embryonal; Melanoma; Glioma; Diffuse Intrinsic Pontine Glioma; Neuroectodermal Tumors, Primitive; Sarcoma; Sarcoma, Clear Cell; Neurofibrosarcoma; Sarcoma, Ewing; Osteosarcoma; Retinoblastoma; Teratoma; Sarcoma, Synovial; Central Nervous System Neoplasms; Wilms Tumor; Diffuse midline glioma; Hepatoblastoma; Rhabdoid Tumor; Desmoplastic Small Round Cell Tumor; Carcinoma; Rhabdomyosarcoma; Medulloblastoma; Solid tumours; Ependymoma
Details
CC-3CC-3Phase 1 ClinicalEberhard Karls University Of Tubingen, GermanyColorectal Neoplasms; Gastrointestinal Neoplasms
Details
KT-095KT-095Phase 1 ClinicalNanjing Kati Medical Technology Co LtdSolid tumours
Details
EX-105EX-105; EX105Phase 1 ClinicalGuangzhou Excelmab IncSolid tumours
Details
IBI-3001IBI-3001; IBI3001Phase 1 ClinicalInnovent Biologics(Suzhou) Co LtdSolid tumours
Details
MGC-026MGC026; MGC-026Phase 1 ClinicalMacrogenics IncProstatic Neoplasms, Castration-Resistant; Neoplasm Metastasis; Uterine Cervical Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Hepatocellular; Melanoma; Endometrial Neoplasms; Colorectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Solid tumours; Small Cell Lung Carcinoma; Neoplasms; Pancreatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Renal Cell; Stomach Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms
Details
Loco-regional B7H3 IL-7Ra CAR T Cell therapy(Chulalongkorn University)Phase 1 ClinicalChulalongkorn University, King Chulalongkorn Memorial HospitalSolid tumours; Neoplasms; Brain Neoplasms; Diffuse Intrinsic Pontine Glioma
Details
Autologous CAR-T Cells Targeting B7-H3(Unc Lineberger Comprehensive Cancer Center)Phase 1 ClinicalUnc Lineberger Comprehensive Cancer CenterOvarian Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Neoplasms; Breast Neoplasms
Details
MT-027MT-027Phase 1 ClinicalT-Maximum Pharmaceutical (Suzhou) Co LtdSolid tumours; Mesothelioma; Glioma; Pleural Neoplasms; Pleural Effusion, Malignant
Details
UTAA06UTAA-06Phase 1 ClinicalPersongen Biotherapeutics (Suzhou) Co LtdLeukemia, Myeloid, Acute
Details
B7-H3 CAR T-cell therapy(Stanford University)B7-H3CARTPhase 1 ClinicalStanford UniversityOvarian Neoplasms; Neuroblastoma; Osteosarcoma; Sarcoma; Nervous System Diseases
Details
TX103 CAR-T cell therapy(Fuzhou Tuoxin Tiancheng Biotechnology)Phase 1 ClinicalFuzhou Tuoxin Tiancheng Biotechnology Co LtdSolid tumours; Glioma
Details
EGFR/B7H3 CAR-TEGFR/B7H3 CAR-TPhase 1 ClinicalSecond Affiliated Hospital Of Guangzhou Medical UniversityTriple Negative Breast Neoplasms; Lung Neoplasms
Details
BAT-8009BAT8009; BAT-8009Phase 1 ClinicalBio-Thera Solutions LtdSolid tumours
Details
TAA-06TAA06-UCAR-γδT; TAA-06Phase 1 ClinicalPersongen Biotherapeutics (Suzhou) Co LtdSolid tumours; Neuroblastoma; Colorectal Neoplasms; Lung Neoplasms; Melanoma
Details
XmAb-808XmAb808Phase 1 ClinicalXencor IncCarcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Transitional Cell; Carcinoma, Ovarian Epithelial; Triple Negative Breast Neoplasms; Prostatic Neoplasms, Castration-Resistant; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung
Details
Anti-CD276 CAR T-cell therapy (Persongen )Phase 1 ClinicalPersongen Biotherapeutics (Suzhou) Co LtdStomach Neoplasms; Small Cell Lung Carcinoma; Osteosarcoma; Neuroblastoma; Lung Neoplasms
Details
Allogenic B7H3-targeting CAR-γδT Cell TherapyQH104 Cell; QH-104 CellClinicalSuzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated To Soochow University)Glioblastoma; Glioma
Details
B7-H3-targeting CAR-T cell therapyBeijing Tiantan Hospital, Capital Medical University
Details
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