HBEGF Overview
Molecule Name
Heparin-binding EGF-like growth factor
Synonyms
HBEGF, HB-EGF, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor, DT-R, DTR, DTS, HEGFL
Drug Development Progress
Drugs in Clinical Trials0
Approved Drugs0
Highest Development StageDiscontinued
Target Synonym
DTS，DTR，HB-EGF，DT-R，Diphtheria toxin receptor，HBEGF，Heparin Binding EGF Like Growth Factor，Diphtheria Toxin Receptor (Heparin-Binding Epidermal Growth Factor-Like Growth Factor)，Heparin-Binding Epidermal Growth Factor，HEGFL，Proheparin-Binding EGF-Like Growth Factor，Heparin-Binding EGF-Like Growth Factor，DTSF，Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor)
Background
Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a ligand for the EGF receptor (EGFR) and a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, adipogenesis. Misexpression of HB-EGF is linked to tumor formation and cancer including hepatocellular, pancreatic, gastric, breast, colon and melanoma, gliomas and glioblastomas.