B21R

Produktanfrage

B21R Molekülhintergrund

Monkeypox is a rare zoonosis caused by monkeypox virus, which has become the most serious orthpoxvirus and consists of complex double stranded DNA. The cases are mostly in central and western Africa. The pathogenesis of monkeypox is that the virus invades the body from respiratory mucosa, multiplies in lymphocytes, and incurs into blood producing transient venereal toxemia. after the virus multiplies in cells, the cells can invade the blood and propagate to the skin of the whole body, causing lesions. The important target protein B21R with key immune dominant epitopes is considered to be the focus of monkeypox virus research.

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
BLU-782	BLU-782; IPN-60130	Phase 2 Clinical	Blueprint Medicines Corp, Ipsen SA	Myositis Ossificans	Details
Zilurgisertib	INCB-000928; INCB-00928	Phase 2 Clinical	Incyte Corp	Anemia; Polycythemia Vera; Myelodysplastic Syndromes; Kidney Diseases; Ossification, Heterotopic; Multiple Myeloma; Myositis Ossificans; Primary Myelofibrosis; Thrombocythemia, Essential	Details
KER-047	KER-047	Phase 1 Clinical	National Center For Advancing Translational Sciences	Anemia, Iron-Deficiency; Myositis Ossificans	Details
Itacnosertib	TP-0184	Phase 1 Clinical	Tolero Pharmaceuticals Inc, Sumitomo Dainippon	Solid tumours; Anemia	Details
BCX-9250	BCX-9250	Phase 1 Clinical	Biocryst Pharmaceuticals Inc	Myositis Ossificans	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Momelotinib Dihydrochloride	CYT-387; GS-0387; GSK-3070785	Approved		Ojjaara, Omjjara	United States	Primary Myelofibrosis; Anemia	Glaxosmithkline Llc, Glaxosmithkline Plc	2023-09-15	Polycythemia; Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung	Details