Cat. No. / Size
Price
Availability
Qty
MSN-HP223-50tests
$640.00
MSN-HP223-25tests
$335.00
Sub-Total:
$ 0
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources

分子别名(Synonym)

MSLN,Mesothelin,MPF

表达区间及表达系统(Source)

PE-Labeled Human Mesothelin (296-580), His Tag (MSN-HP223) is expressed from human HEK293 cells. It contains AA Glu 296 - Gly 580 (Accession # AAH09272). It is the PE labled form of Human Mesothelin (296-580), His Tag.

Predicted N-terminus: Glu 296

Request for sequence

蛋白结构(Molecular Characterization)

Online(Glu 296 - Gly 580) AAH09272

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 33.0 kDa.

Conjugate

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 10 mM Tris, 150 mM NaCl, 0.1% BSA, pH8.2. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.