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ILDR2,C1orf32
Mouse ILDR2, His Tag (IL2-M52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 36 - Glu 201 (Accession # B5TVM2-1).
Predicted N-terminus: Leu 36
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 20.5 kDa.
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ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.