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FGF-3,HBGF-3,Fibroblast growth factor 3
Human FGF-3, His Tag (FG3-H5247) is expressed from human 293 cells (HEK293). It contains AA Ala 18 - His 239 (Accession # P11487-1).
Predicted N-terminus: His
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 26.8 kDa.
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Please see Certificate of Analysis for specific instructions.
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Fibroblast growth factor 3 (FGF3), belonging to the family of fibroblast growth factors (FGFs), regulates several developmental processes, including brain patterning, branching morphogenesis and limb development, by binding, dimerizing and activating cell surface FGF receptors (FGFRs). FGF/FGFR complexes have been demonstrated to act as driving oncogenes in certain types of cancer to maintain the malignant properties of tumor cells in a cell autonomous manner. According to previous studies, it is speculated that FGF3 is upregulated in breast cancer and accelerates tumor growth and angiogenesis. Consequently, FGF3 has been considered as a potential target for breast cancer therapy.