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分子别名（Synonym）
PAP-S,Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase,VP39,Poly(A) polymerase regulatory subunit,Full=Poly(A) polymerase small subunit
表达区间及表达系统（Source）
Vaccinia Virus Cap-2’-O-Methyltransferase, His Tag (CAE-V5141) is expressed from E. coli cells. It contains AA Met 1 - Lys 333 (Accession # Q76ZT1.1).
Predicted N-terminus: Met
蛋白结构（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 41.1 kDa.
内毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
制剂（Formulation）
Please contact us for detailed information.
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存储（Storage）
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- The product MUST be stored at -70°C or lower upon receipt;
- -70°C for 3 months under sterile conditions.
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Background Introduction
Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.
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