Cellectra™ Human TCRαβ NanoDeplet Microbeads, Research grade

Cellectra™ Human TCRαβ NanoDeplet Microbeads, Research grade are dextran-coated superparamagnetic iron oxide nanoparticles of which the surface is conjugated with recombinant monoclonal antibodies specific to human TCRαβ (Isotype: mouse IgG1). They are especially designed for the depletion of TCRαβ+ cells.
Cellectra™ Human TCRαβ NanoDeplet Microbeads, Research grade are produced under sterile manufacturing conditions (ISO 5), and no animal- or human-derived components are used throughout the production process. It is produced under our rigorous quality control system that includes a comprehensive set of tests including sterility and endotoxin tests.

Cellectra™ Human TCRαβ NanoDeplet Microbeads, Research grade are designed for the depletion of TCRαβ⁺ cells from fresh or frozen human peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) or other cell products. TCRαβ represents the hallmark receptor complex on nearly all adaptive CD4 helper and CD8 cytotoxic T cells, and functions as the primary effector marker driving graft-versus-host disease (GVHD) and allogeneic rejection. Conventional CD3 depletion reagents remove all T cell subsets indiscriminately. In contrast, this microbead product enables targeted elimination of solely TCRαβ+ adaptive T cells, completely retaining intact populations of γδ T cells, NK cells, B cells, monocytes and dendritic cells for unconfounded innate immune research. The magnetic Microbeads are conjugated with monoclonal antibodies targeting human TCRαβ protein, enabling TCRαβ+ cells to be labeled with the specific antibodies and magnetic particles, and separated using the separation columns and magnets.

For long term storage, the product should be stored in liquid state at -20°C or below Stability upon receipt: Stable for 12 months at -20 °C or below; Stable for 3 months at 2–8 °C under sterile conditions.

Please protect from light and avoid repeated freeze-thaw cycles.

Negative

Less than 2 EU per mL by the LAL method / rFC method.

Negative

This product is for research use only and not intended for therapeutic or in vivo diagnostic use.

Supplied in PBS buffer containing EDTA, rHSA and Poloxamer 188.