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Anti-B7H3 ADC

BLA Filing
  • Project profile
    Project name: Anti-B7H3 ADC
    Indications: Broad cancer
    Research phase: PCC
    Cooperation demands: License-out or co-development the global right
  • Highlights

    1. Clear MOA

    (1) The B7H3 protein (encoded from the CD276 gene) is a checkpoint molecule that is highly expressed in solid tumors, with reportedly limited expression in normal tissues. Overexpression of B7H3 is correlated with tumor progression, metastasis, and poor clinical outcome across a variety of malignancies.

    (2) Monoclonal antibodies targeting B7H3 cause limited toxicity and have demonstrated some anti-tumor activity in clinical trials. Anti-B7H3 ADC can get better anti-tumor effect than anti-B7H3 mAb.

    2. Antibodies specific binding to human B7H3 protein

    Both anti-B7H3 are strong in binding to human B7H3. And anti-B7H3 #2’s affinity to mouse B7H3 is 100-fold weaker than Human B7H3.

    3. High selectivity and affinity

    (1) Both anti-B7H3’s cell-based affinity binding of 1-2 digit nano-molar was observed across cell lines. And No non-specific binding was observed on a target-negative cell line.

    (2) No non-specific binding to other family members.

    4. Induced strong B7H3 internalization on tumor cells.

    5. Anti-B7H3 ADC showed strong potency in target-expressing cell lines, but weak potency in target-negative cell line, comparable to the isotype control ADC.

    6. Good thermostability

  • Project Introduction

    1. Asset type: Anti-B7H3 ADC, 2 antibody sequences

    2. Indication: Broad cancer

    3. Modality: Small molecular

    4. Research phase: Phase 1, IP has been granted in US, AU, CN

    5. Cooperation demands: License-out or co-development

    6. Research progress:

    (1) Anti-B7H3 #2 (MMAE) ADC showed strong potency in target-expressing cell lines. Potency on a target-negative cell line was minimal and comparable to the isotype control ADC.
    (2) Camptothecin ADCs: DAR8 conjugation was achieved. Both, Anti-B7H3 #1 and #2, showed some differential potency as Camptothecin ADCs over isotype control ADC in Calu-6 and HEC-251 cells.

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