Human TOP2A / TOP2 Protein, Tag Free

Product Number/Spec
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Menge
TOA-H5117-20ug
$310.00
In Stock - Delivery in 1-2 business days
TOA-H5117-100ug
$1,010.00
In Stock - Delivery in 2-3 weeks
TOA-H5117-500ug
$3,625.00
In Stock - Delivery in 2-3 weeks
TOA-H5117
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Synonyms

TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme

Source

Human TOP2A, Tag Free (TOA-H5117) is expressed from E. coli cells. It contains AA Ser 1354 - Ser 1473 (Accession # P11388-1).

Predicted N-terminus: Met

Molecular Characterization

This protein carries no "tag".

The protein has a calculated MW of 13.0 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).

Purity

>90% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 0.5 M KCl, pH8.0 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.

Background Introduction

DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.