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Product Details
Synonyms
PTK7, CCK4, CCK-4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7
Source
Rabbit PTK7, His Tag (PT7-R52H4) is expressed from human 293 cells (HEK293). It contains AA Ala 31 - Thr 612 (Accession # G1SIJ6-1).
Predicted N-terminus: Ala 31
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 66.4 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Shipping and Storage
This product is shipped at ambient temperature.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Data Display
SDS-PAGE
Rabbit PTK7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-MALS
The purity of Rabbit PTK7, His Tag (Cat. No. PT7-R52H4) is more than 85% and the molecular weight of this protein is around 85-103 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Rabbit PTK7, His Tag (Cat. No. PT7-R52H4) at 1 μg/mL (100 μL/well) can bind Cofetuzumab Pelidotin with a linear range of 0.2-4 ng/mL (QC tested).
Protocol
Bioactivity-SPR
Cofetuzumab captured on Protein A Chip can bind Rabbit PTK7, His Tag (Cat. No. PT7-R52H4) with an affinity constant of 88.5 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Protocol
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Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Protein-tyrosine kinase 7
- Category：
- Listed Drugs Count：
0 Details
- Clinical Drugs Count：
8 Details
- Highest R&D Stage：
Phase 2 Clinical
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