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Human PRMT5 & MEP50 Protein, Flag,His Tag (MALS verified)

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Menge
PR5-H55D3-100ug
$350.00
In Stock - Delivery in 1-2 business days
PR5-H55D3-1mg
$2,310.00
In Stock - Delivery in 2-3 weeks
PR5-H55D3
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Synonyms

HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs

Source

Human PRMT5 & MEP50 Protein, Flag,His Tag (PR5-H55D3) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Leu 637 & Arg 2 - Glu 342 (Accession # O14744-1 & Q9BQA1).

Predicted N-terminus: Met & Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

The PRMT5 & MEP50 protein carries a Flag tag and a polyhistidine tag at the N-terminus. The protein has a calculated MW of 74.4 kDa & 38.3 kDa. The protein migrates as 40-43 kDa and 65-75 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

The protein is designed as a heterodimer.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 500 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background Introduction

Protein arginine methyltransferase 5 (PRMT5) is a type II enzyme that catalyzes symmetric dimethylation of arginine residues on histone and non-histone proteins. It forms a hetero-octameric complex with its essential cofactor MEP50 (methylosome protein 50), which enhances its catalytic activity and substrate selectivity. The PRMT5–MEP50 complex regulates gene expression epigenetically, influences RNA splicing, and modulates signal transduction pathways. Aberrant PRMT5–MEP50 activity is linked to tumorigenesis, cardiovascular disorders, and neurodegeneration by driving dysregulated methylation patterns that favor cell proliferation and survival.