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Influenza A virus (strain A/Victoria/3/1975 H3N2) Polymerase acidic Protein, His Tag

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Menge
PON-V51H3-100ug
$380.00
In Stock - Delivery in 1-2 business days
PON-V51H3-1mg
$2,800.00
In Stock - Delivery in 2-3 weeks
PON-V51H3
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Synonyms

Polymerase acidic protein

Source

Influenza A virus (strain A/Victoria/3/1975 H3N2) Polymerase acidic Protein, His Tag (PON-V51H3) is expressed from E. coli cells. It contains AA Met 1 - Gly 209 (Accession # P31343-1).

Predicted N-terminus: Met 1

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 26.5 kDa. The protein migrates as 28-30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).

Purity

>90% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in PBS, 0.5 M Arginine, Glycerol, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background Introduction

Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.