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COADS MSDS

Human Nectin-4 Protein, Fc Tag, low endotoxin (MALS verified)

AIDD‑Ready
Related Products: Cell line CHEK-ATP035
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COADS MSDS
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NE4-H5255-100ug
$415.00
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NE4-H5255-1mg (500ug X 2)
$2,615.00
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NE4-H5255
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

NECTIN4, LNIR, PRR4, PVRL4

Source

Human Nectin-4, Fc Tag (NE4-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1).

Predicted N-terminus: Gly 32

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 60.5 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Nectin-4 (Nectin Cell Adhesion Molecule 4) is a member of the nectin family of immunoglobulin-like cell adhesion molecules. It is highly expressed during embryonic development but shows limited expression in most normal adult tissues. Nectin-4 is overexpressed in a variety of solid tumors, including bladder, breast, lung, pancreatic and ovarian cancers, and has been associated with tumor growth, invasion and metastasis. Studies have shown that Nectin-4 contributes to tumor progression through multiple signaling pathways, including PI3K/Akt signaling. Due to its restricted expression in normal tissues and elevated expression in malignant tumors, Nectin-4 has emerged as an attractive therapeutic target for cancer diagnosis and treatment.