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Human IL-36 gamma / IL-1F9 Protein, Tag Free (MALS verified)

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Product Number/Spec
Price
Menge
IL9-H5115-100ug
$310.00
IL9-H5115-1mg
$2245.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    IL36G, IL-1RP2, IL-1 epsilon, IL-1F9, IL-1H1, IL1E, IL1F9, IL1H1, IL1RP2

  • Source

    Human IL-36 gamma Protein, Tag Free (IL9-H5115) is expressed from E. coli cells. It contains AA Ser 18 - Asp 169 (Accession # Q9NZH8-1).

    Predicted N-terminus: Ser 18

    Request for sequence
  • Molecular Characterization

    IL-36 gamma Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries no "tag".

    The protein has a calculated MW of 17.0 kDa. The protein migrates as 15-16 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    IL-36 gamma SDS-PAGE

    Human IL-36 gamma Protein, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-36 gamma SEC-MALS

    The purity of Human IL-36 gamma Protein, Tag Free (Cat. No. IL9-H5115) is more than 90% and the molecular weight of this protein is around 15-25 kDa verified by SEC-MALS.

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Publish Comment

Background Introduction

The IL-36 subfamily of cytokines is the most diverse, including three agonists(IL-36α, IL-36β, and IL-36Γ), one antagonist(IL-36Ra), one cognate receptor(IL-36R) and one accessory protein(IL-1RAcP). The receptor activation follows a two-step mechanism in that the agonist first binds to IL-36R and the resulting binary complex recruits IL-1RAcP. IL-36γ that binds to and signals through the IL-36R which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Appropriately balanced IL-36 signaling is a critical determinant of skin and lung health.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Interleukin-36 gamma

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    1 Details

  • Highest R&D Stage:

    Phase 1 Clinical

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