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PE-Labeled Human HLA-A*24:02&B2M&EBV EBNA3A (RYSIFFDYM) Tetramer Protein

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HLA-HP2H8-25ug
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HLA-HP2H8-200ug (100ug X 2)
$2,350.00
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Synonyms

HLA-A*2402 & B2M & EBV EBNA3A (RYSIFFDYM)

Source

PE-Labeled Human HLA-A*24:02&B2M&EBV EBNA3A (RYSIFFDYM) Tetramer Protein (HLA-HP2H8) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Thr 305 (HLA-A*24:02) & Ile 21 - Met 119 (B2M) & RYSIFFDYM peptide (Accession # AAA59600.1 (HLA-A*24:02) & P61769 (B2M) & RYSIFFDYM).

Predicted N-terminus: Gly 25 & Arg

Molecular Characterization

PE-Labeled Human HLA-A*24:02&B2M&EBV EBNA3A (RYSIFFDYM) Tetramer Protein is assembled by biotinylated monomer (HLA-H82E4) and PE-labeled streptavidin.

Biotinylated Human HLA-A*24:02&B2M&EBV EBNA3A (RYSIFFDYM) Complex Protein is produced by co-expression of HLA and B2M loaded with EBV EBNA3A peptide. Biotinylated Human HLA-A*24:02&B2M&EBV EBNA3A (RYSIFFDYM) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

Conjugate

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, 1% BSA, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background Introduction

Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. The Human HLA-A*2402 EBV EB3A (RYSIFFDYM) complex protein is a complex of HLA-A*2402 of the MHC Class I, B2M and RYSIFFDYM peptide of the EBV EB3A.