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Unconjugated Human HLA-A*02:01&B2M&EBV LMP2A (CLGGLLTMV) Complex Protein (Monomer, MALS verified)

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HLA-H82Ea-25ug
$125.00
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HLA-H82Ea-200ug
$700.00
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HLA-H82Ea
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Product Details
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  • Product Details
  • Performance Data
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Synonyms

HLA-A*0201 & B2M & EBV LMP2A (CLGGLLTMV)

Source

Unconjugated Human HLA-A*02:01&B2M&EBV LMP2A (CLGGLLTMV) Complex Protein (HLA-H82Ea) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Ile 308 (HLA-A*02:01) & Ile 21 - Met 119 (B2M) & CLGGLLTMV peptide (Accession # AAA59606.1 (HLA-A*02:01) & P61769-1 (B2M) & CLGGLLTMV).

Predicted N-terminus: Gly 25 & Ile 21

Molecular Characterization

Unconjugated Human HLA-A*02:01&B2M&EBV LMP2A (CLGGLLTMV) Complex Protein is produced by co-expression of HLA-A*02:01 and B2M loaded with EBV LMP2A peptide.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™), and it is not biotinylated.

The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 38-43 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
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Background

Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. Epstein-Bar Virus (EBV), also known as human herpesvirus 4, belongs to gamma herpes virus family and is a very common human virus worldwide. EBV causes infectious mononucleosis (IM) and also associates to some specific types of cancers such as Burkitt’s lymphoma (BL) and gastric carcinoma (GC). Glycoprotein B (gB) plays an important role in viral entry by binding with αvβ6/αvβ8 integrins to trigger the membrane fusion and entry process of epithelial cells, which makes it become an great target for EBV research. The Human HLA-A*0201 EBV LMP2A (CLGGLLTMV) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M and CLGGLLTMV peptide of the EBV LMP2A.