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Mouse Fc epsilon RI alpha Protein, Fc Tag

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FCA-M5253-100ug
$300.00
In Stock - Delivery in 2 weeks
FCA-M5253-1mg (500ug X 2)
$1,980.00
In Stock - Delivery in 2 weeks
FCA-M5253
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

FCER1A, FCE1A, FcERI

Source

Mouse Fc epsilon RI alpha Protein, Fc Tag (FCA-M5253) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Gln 204 (Accession # P20489).

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 47.6 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 225 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Fc epsilon RI alpha (FcεRIα) is the α-chain of the high-affinity IgE receptor (FcεRI), a critical mediator of type I hypersensitivity. As a transmembrane glycoprotein in the immunoglobulin superfamily, its extracellular domain specifically binds the Fc region of IgE. Mainly expressed on mast cells and basophils, FcεRIα cross-linking (by IgE-allergen complexes) triggers cell degranulation, releasing histamine and proinflammatory mediators—driving allergies, asthma, and anaphylaxis. It also participates in immune surveillance. Owing to its central role in allergic responses, FcεRIα is a key therapeutic target for anti-allergy agents.