Monoclonal Anti-Epstein-Bar Virus (EBV) gH&gL Antibody, Human IgG1 (8C5) (MALS verified)

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Cat. No. / Size
Price
Qty
GHL-MY2403-100ug
$350.00
GHL-MY2403-1mg (500ug X 2)
$2310.00
ETA of in-stock products:2 business days

Product Details

  • Source

    Monoclonal Anti-Epstein-Bar Virus (EBV) gH&gL Antibody, Human IgG1 (8C5) is a recombinant chimeric monoclonal antibody expressed in HEK293, which combines the variable region of a mouse monoclonal antibody with human constant domain.

  • Antibody Type

    Recombinant Monoclonal

  • Clone

    8C5

  • Isotype

    Human IgG1, Kappa

  • Host Species

    Mouse

  • Reactivity

    Virus

  • Immunogen

    Recombinant Epstein-Barr virus Glycoprotein H&Glycoprotein L Heterodimer Protein is expressed from human 293 cells

  • Specificity

    Specifically recognizes Epstein-Barr virus Glycoprotein H&Glycoprotein L Heterodimer Protein.

  • Application

    Application
    Recommended Usage
    Western Blot
    0.5-0.02 μg/mL
    ELISA
    0.2-2 μg/mL
  • Purification

    Protein A purified / Protein G purified.

  • Aggregation

    Less than 5%, as determined by SEC-MALS.

  • Concentration

    Please refer to the Certificate of Analysis (CoA).

  • Form

    Lyophilized

  • Formulation

    Lyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.

    Please contact us for customized product forms or formulations.

  • Reconstitution

    Please refer to the Certificate of Analysis (CoA) for specific instructions.

  • Shipping

    Lyophilized product is shipped at ambient temperature.

  • Storage

    For long term storage, the product should be stored in a lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Notices

    Product Specific Notices: For research use only.

  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • Bioactivity-ELISA

     Glycoprotein H & Glycoprotein L/gH & gL (EBV) ELISA

    Immobilized Epstein-Barr virus Glycoprotein H&Glycoprotein L Heterodimer Protein, Twin-Strep&His Tag (Cat. No. GHL-E5283) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Epstein-Bar Virus (EBV) gH&gL Antibody, Human IgG1 (8C5) (Cat. No. GHL-MY2403) with a linear range of 0.05-2 ng/mL (QC tested).

    Protocol
  • Western Blot

     Glycoprotein H & Glycoprotein L/gH & gL (EBV) WESTERN BLOT
  • Detection of Monoclonal Anti-Epstein-Bar Virus (EBV) gH&gL Antibody, Human IgG1 (8C5) by Western Blot. Monoclonal Anti-Epstein-Bar Virus (EBV) gH&gL Antibody, Human IgG1 (8C5) at 0.02 μg/mL dilution + Epstein-Barr virus Glycoprotein H&Glycoprotein L Heterodimer Protein, Twin-Strep&His Tag at 400 ng.
    Secondary Antibody: (HFC)-Peroxidase AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1/2000 dilution.
    Predicted band size: 55 | 95 kDa 12% Bis-Tris Protein Gel

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Background

The Epstein–Barr virus (EBV) glycoproteins H (gH) and L (gL) form a heterodimer essential for viral entry into host cells. This complex mediates membrane fusion in cooperation with other viral glycoproteins, enabling EBV to infect both B lymphocytes and epithelial cells. Antibodies targeting gH/gL can block this fusion process, thereby neutralizing infection. Such antibodies are valuable tools for studying EBV pathogenesis, evaluating vaccine candidates, and developing diagnostic assays. Because gH/gL are conserved and exposed on the viral envelope, they elicit strong immune responses, making anti‑gH/gL antibodies important in both research and potential therapeutic applications.

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