MIS RII Molekülinformation
Molecule Name
Anti-Mullerian hormone receptor II
Molekülalias
MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor
Drug Development Progress
Anzahl der klinischen Arzneimittel0
Anzahl der inverkehr gebrachten Arzneimittel0
Höchste Forschungs- und EntwicklungsphasePreclinical
Target-Alias
Anti-Mullerian Hormone Receptor， Type II，AMHR2，MRII，AMH Type II Receptor，MISRII，Muellerian Inhibiting Substance Type II Receptor，MIS Type II Receptor，Anti-Muellerian hormone type-2 receptor，EC:2.7.11.30，Mullerian Inhibiting Substance Type II Receptor，MISR2，AMHR，Anti-Muellerian Hormone Type-2 Receptor，Anti-Mullerian Hormone Receptor Type 2，EC 2.7.11.30，Anti-Muellerian Hormone Type II Receptor，Anti-Mullerian Hormone Receptor Type II
Molekülhintergrund
MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.
MIS RII Produktliste
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K***n2025-04-29We purchased this protein and validated its binding to its natural ligand, MIS. We saw great binding between the hMISRII-hFc and MIS ligand, which was exactly what we expected. Additionally, this protein passed our QC requirements for purity on SDS-PAGE and SEC. This was purchased along with several other MISRII products from other companies and this was the only material that bound MIS with expected affinity. As such, we plan to use this protein for our downstream applications.