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Your Position: Start > Protein > Nectin-4 > NE4-M52H3

Mouse Nectin-4 Protein, His Tag (MALS verified)

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  • Synonym
    NECTIN4,LNIR, PRR4, PVRL4
  • Source
    Mouse Nectin-4, His Tag(NE4-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 31 - Ser 347 (Accession # Q8R007-1).
    Predicted N-terminus: Gly 31
  • Molecular Characterization
    Nectin-4 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 36.2 kDa. The protein migrates as 38-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Nectin-4 SDS-PAGE

Mouse Nectin-4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Nectin-4 MALS images

The purity of Mouse Nectin-4, His Tag (Cat. No. NE4-M52H3) is more than 85% and the molecular weight of this protein is around 35-55 kDa verified by SEC-MALS.

Bioactivity-BLI
 Nectin-4 BLI

Loaded Mouse Nectin-4, His Tag (Cat. No. NE4-M52H3) on NTA Biosensor, can bind Human Nectin-1, Fc Tag (Cat. No. PV1-H5253) with an affinity constant of 48.8 nM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

  • Background
    Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
  • Clinical and Translational Updates

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  • Latest Research Phase:Approved

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