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1. MoA：
When tumor cachexia occurs, the TGF-β family ligands in the blood activate ActRIIB (activin II receptor B) on the skeletal muscle cell membrane, activate various forms of protein degradation, and inhibit protein synthesis;
ActRIIB inhibitors can significantly inhibit ActRIIB activity, effectively block the MSTN/ActRIIB signaling pathway, reduce muscle atrophy and improve grip, thus alleviate symptoms of tumor cachexia.
Highlight：
1. Great ActRIIB kinase inhibition ability (nM level);
2. Effectively alleviate atrophy of C2C12 myotubes induced by culture supernatant of C26 and LLC tumor cells;
3. Effectively alleviate atrophy of C2C12 myotubes induced by TGF-β family ligands MSTN (GDF-8) and TGF-β1;
4. PK test indicates good oral absorption;
5. Effectively alleviate weight loss and muscle atrophy in C26 tumor bearing mice with cachexia, restore muscle strength in mice, and improve symptoms of cachexia.
1. Asset type: ActRIIB inhibitor
2. Indication: Cancer cachexia
3. Modality:Small molecule
4. Research:Pre-clinical
5. Demands： License-out or co-development
Highlight：
1. Great ActRIIB kinase inhibition ability (nM level);
2. Effectively alleviate atrophy of C2C12 myotubes induced by culture supernatant of C26 and LLC tumor cells;
3. Effectively alleviate atrophy of C2C12 myotubes induced by TGF-β family ligands MSTN (GDF-8) and TGF-β1;
4. PK test indicates good oral absorption;
5. Effectively alleviate weight loss and muscle atrophy in C26 tumor bearing mice with cachexia, restore muscle strength in mice, and improve symptoms of cachexia.
ACROBiosystems offers a wide selection of Matrigengel basement membrane extracts. Different versions – including phenol red-free, high concentration, iPSC culturing, organoid culturing – are all available for your specific needs to support 3D cell culture!
ComboX is a new brand of ACROBiosystems. ComboX products include our Streptavidin series products, coated plates, isotype controls for antibody and fusion protein drug research, and general-purpose antibodies.
To enable antibody characterization methodsACROBiosystems has developed a series of enzymes.such as ldeS, SpeB, EndoH, and Endo S proteases, toassist with the characterization of antibodies and theirrelated post-translational modifications (PTMs)
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
Comprehensive cytokine targets including interleukins, growth factors, chemokines, TNFs, etc. are expressed by HEK293 to ensure their natural structure. Their high purity is verified by SDS-PAGE/HPLC/SEC-MALS and high bioactivity is verified by ELISA/SPR/BLI.
Aneuro is ACROBiosystems brand focused on neuroscience research, providing high-quality important proteins including therapeutic and diagnostic research proteins, PFFs and recombinant neuro factors, etc. to advance neuroscience research.
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